中药安替可配合放射治疗食管癌的近期疗效观察

Observation of The Close Effect of Radiotherapy Combined with Antike on Esophageal Carcinoma

目的 :评价中药安替可对食管癌的放疗增敏作用及毒副作用。方法 :6 4例确诊为食管癌的患者被随机分为治疗组 (放射治疗 +中药安替可 )和对照组 (单纯放射治疗 ) ,根据放疗半量及全量时肿瘤的消退情况 ,比较两组的有效率及全消率 ,做为增敏的评价指标。两组患者的放疗剂量均为DT总量 6 0～ 6 5Gy。治疗组在放疗同时口服安替可胶囊 ,每天 3次 ,每次 0 .4 4 ,连服 5周。结果 :放疗半量时 ,治疗组有效率 6 2 .5% ,对照组 12 .5% ,P <0 .0 0 1;放疗全量时 ,治疗组肿瘤完全缓解率 75% ,对照组 37 5% ,P <0 .0 5。在毒性反应方面 ,治疗组恶心、呕吐等胃肠道反应较多。结论 :中药安替可对食管癌的放疗有显著增敏作用 。

Objective:To evaluate the radiosensitizing effect and the toxicity of ANTIKE in the radiotherapy of esophageal carcinoma.Methods:64 cases of pathologically cenformed esophageal carcinoma were randomized into study group and control group, the patients in study group were treated with radiotherapy combined ntike,patients in the control group received radiotherapy alone,CR and PR were regarded as endpoints to evaluate the radiosensitization of Antike,when the patients received half dosage and total dosage.Results:Half dosage:the effective rate in study group was 62.5%,12.5% in control group, P <0.001;Total dosage:CR in study group was 75%,and 37.5% in control group, P <0.01.Patients in study group had more gastrointestinal side effects such as nausea、vomiting and diarrhea.Conclusions:Antike has radiosensitizing effect on esophageal carcinoma.