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PI3K-Akt-mTORC1信号途径在细胞生长增殖中的调控作用 被引量：7

Regulation of PI3K-Akt-mTORC1 signal pathway in the cell growth and proliferation
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摘要 PI3K-AKT-mTORC1信号途径在细胞生长增殖中起重要调控作用,PI3K-Akt-mTOR1信号途径能够调节细胞周期相关蛋白基因的表达来调控细胞的增殖;同时,PI3K-Akt-mTOR1信号途径也能够调控细胞的生长和大小;PI3K-Akt-mTORC1信号途径的异常活化与肿瘤发生紧密相关。就PI3K-AKT-mTORC1信号途径在细胞生长增殖中的作用作一综述。 PI3 K-Akt-mTOR1 signal pathway plays an important role in the cell growth and proliferation. PI3 K-Akt-mTOR1 signal path- way could regulate the cell proliferation by modulating the gene expression of the protein related to cell cycle regulation and by regula- ting cell growth and cell size. In addition, the abnormal activation of PI3K-Akt-mTOR1 signal pathway is related to tumorigenesis tumor. In this paper, the role of PI3K-AKT-mTORC1 signal pathway in cell growth and proliferation was reviewed.
作者 黎丽 韩春春 刘秀云
机构地区 成都农业科技职业学院 四川农业大学动物遗传育种所 山东省安丘市青云学府
出处 《生物学杂志》 CAS CSCD 2014年第1期75-77,共3页 Journal of Biology
基金 高等学校博士学科点专项科研基金(No.20115103120006)
关键词 P13K-AKT-mTORCl信号途径 生长增殖 调控 PI3K-Akt-mTOR1 signal pathway growth and proliferation regulation
分类号 Q257 [生物学—细胞生物学]
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参考文献23

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二级参考文献33

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生物学杂志
2014年 第1期

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