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脆性X综合征代谢性谷氨酸受体信号通路与认知障碍关系进展 被引量：1

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摘要 脆性X综合征（fragile X syndrome,FXS）是一种常见的遗传性智力低下疾病,认知障碍是其主要临床表现之一.目前认为,代谢性谷氨酸受体（metabotropic glutamate receptor,mGluR）信号通路的异常激活是FXS各种临床症状的主要原因.探讨并总结mGluR及下游信号通路改变与学习记忆障碍的关系可为FXS的治疗提供更有效的靶点,本文拟综述如下.
作者 张瑾 陈盛强
机构地区 广州医科大学附属第二医院神经内科
出处 《广东医学》 CAS CSCD 北大核心 2014年第2期300-302,共3页 Guangdong Medical Journal
基金 广东省第一批产业技术研究与开发资金计划项目(编号:2008B030301371)
关键词 代谢性谷氨酸受体 受体信号通路 脆性X综合征 认知障碍 receptor 学习记忆障碍 MGLUR 智力低下
分类号 R651.15 [医药卫生—外科学]
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参考文献25

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二级参考文献28

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共引文献6

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广东医学
2014年 第2期

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