摘要
开展了水相中硝基烯烃与氨基吡啶反应生成咪唑并[1,2-α]吡啶衍生物的微波辅助合成研究。结果表明:相同反应时间,在微波辅助条件下,生成咪唑并[1,2-α]吡啶衍生物的速率较常规加热条件下增大。一系列咪唑并[1,2-α]吡啶衍生物被高效的合成出来,最高产率达到85%。产物结构经~1H NMR,^(13)C NMR及MS得到确证。该方法具有产率高、操作简单、环境友好等优点。
Microwave-assisted organic synthesis of imidazo [1,2-α] pyridines derivatives through the reaction of nitrostyrene with aminopyridine in water was investigated.The results showed the yield was improved significantly when the reaction was carried out under microwave irradiation.A variety of imidazo[1,2-α]pyridines could be synthesized in good to excellent yields up to 85%.The structures of all compounds were confirmed by 1 H NMR, 13 C NMR and MS analysis.This method had the advantages of good yields , easy work-up and environmentally friendly procedure.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2014年第2期281-285,共5页
Chemical Research and Application
基金
福建医科大学博士启动基金项目(2011BS006)资助
福建省科技厅研究基金项目(2012J05150)资助