预防性雾化吸入对胸腹部手术术后患者肺部并发症发生率影响的Meta分析

Influence of preoperative ambroxol aerosol inhalation on postoperative lung complications：a Meta analysis

目的 评价术前雾化吸入对胸腹部手术患者术后肺部并发症发生率的影响.方法 计算机检索中国学术期刊全文数据库、中国科技期刊全文数据库、万方科技期刊全文数据库,收集研究术前使用雾化吸入对胸腹部手术患者术后肺部并发症发生率影响的随机对照实验,采用RevMan5.0软件进行统计处理.结果 共纳入文献1 1篇,1 160例患者.资料存在一定异质性,其中纳入人群、雾化吸入方式、药物、具体吸入时间等因素均可能为影响胸腹部手术患者术后肺部并发症发生的主要因素.研究结果显示,预防性使用雾化吸入治疗能够有效地降低术后肺部并发症发生率.结论 预防性使用雾化吸入治疗能够降低术后肺部并发症发生率,但这一研究结果需要更高质量的研究作支撑.

Objective To evaluate the effect of preoperative ambroxol aerosol inhalation on postoperative lung complications in patients with chest and abdominal surgery.Methods The randomized controlled trials （RCTs） taking preoperative ambroxol aerosol inhalation interventions were collected from the databases of Chinese Technology Journal Database,China National Knowledge Internet and Wanfang Database.Data were analyzed with RevMan 5.0 software.Results Eleven articles with 1 160 patients met the inclusion criteria.There was a certain heterogeneity across the analysis,which might result from kind of included patients,inhalation method,difference of the medication,inhalation time,etc,according to subgroup analysis.The result showed that compared with the control group,patients in the experimental group had lower incidence of postoperative lung complications and the differences were not statistically significant.Conclusions The Meta analysis had identified a significant effect of preoperative ambroxol aerosol inhalation on postoperative lung complications in patients with chest and abdominal surgery,but high quality were in need.