连续性血液净化疗法在烧伤脓毒血症治疗中的临床效果分析

Clinical Application of Continious Blood Purification Therapy in Severe Burn with Sepsis

目的探讨应用连续性血液净化疗法(CBP)对严重烧伤脓毒血症患者的疗效。方法 48例重症烧伤脓毒血症患者随机分为血液净化组和对照组,每组各24例,两组均经常规治疗,血液净化组在常规治疗的基础上CBP治疗。观察两组患者治疗前后实验室检查,包括血常规、电解质、血糖、血尿素氮、血肌酐检测及白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的浓度检测。结果血液净化组患者治疗后血常规、电解质、血糖、血尿素氮、血肌酐、IL-6、TNF-α的数据较对照组治疗后有明显改善,差异有统计学意义(P<0.05)。结论连续性血液净化疗法能够降低炎性介质,改善脏器功能,从而改善烧伤脓毒血症患者的反应过程及预后,是治疗严重烧伤脓毒血症的有效措施之一。

Objective To evaluate the effect of continous blood purification therapy（CBP） on severely burned patients with sepsis. Methods All the 48 cases of severe bum sepsis patients were randomly divided into blood purification group and routine treatment group. Each of the 24 patients in the control group accepted conventional treatment, while the experimental group accepted continues blood purification therapy. Laboratory tests included blood routine, electrolytes, blood glucose（GLU）, blood urea nitrogen （BUN）, blood creatine （Cr） and interleukin-6 （IL-6）, tumor necrosis factor-a （TNF-o0. Results Vital signs of blood purification therapy patients significantly improved, and blood purification, electrolytes, BUN, Cr, IL-6, TNF-c~ decreased significantly after treatment, with statistically significant difference （P 〈0.05） compared with the conventional treatment group. Conclusions Continuous blood purification can not only reduce inflammatory mediators, but also improve organ function and the reaction process of burn patients with sepsis and prognosis. It is one of the effective measures for treatment of severe burn with sepsis.