维生素D与肝脏疾病的相关性研究进展

Research Progress of the Correlation between Vitamin D and Liver Diseases

近30余年来,有关维生素D的生物学特性及作用等研究发展迅速,维生素D主要参与血钙调节,维持骨骼稳态。近些年逐渐认识到维生素D同样能调节细胞增殖、分化,具有免疫调节、抗炎及抗纤维化等作用。研究表明,这些生理功能与慢性肝脏疾病发病机制和治疗有关。本文主要阐述维生素D与肝脏疾病:如自身免疫性肝病、非酒精性脂肪性肝病、慢性乙型肝炎、慢性丙型肝炎、酒精性肝病、肝脏恶性肿瘤等的相关性。

Scientific researches on biological characteristics and functions of vitamin D have been greatly developed in recent 30 years, vitamin D mainly participate in blood calcium regulation and maintain bone homeostasis. In recent years, there is increasing recognition that vitamin D also regulates cell proliferation and differentiation, and can optimize immune response, has anti - inflammatory and anti - fibrosis effects. Research shows that physiological functions of vitamin D are related to the pathogenesis and treatment of chronic liver diseases. This article reviews correlation between vitamin D andautoimmune liver disease, non-alcoholic fatty liver disease, chronic hepatitis B, chronic hepatitis C, alcoholic liver disease, hepatic malignant tumors and other liver diseases.