氨溴索对慢性阻塞性肺疾病急性发作患者呼吸功能及炎性应激的影响

Influence of ambroxol for the respiratory function and inflammatory stress of patients with chronic obstructive pulmonary disease at acute stage

目的:研究探讨氨溴索对慢性阻塞性肺疾病(COPD)急性发作患者呼吸功能及炎性应激的影响。方法:选取本院收治的70例COPD急性发作患者为研究对象,将其随机分为对照组(COPD常规治疗组)35例和观察组(常规治疗加氨溴索组)35例,然后将两组治疗前与治疗后第3天、第7天时的呼吸功能及血清炎性应激指标进行检测与比较。结果:观察组治疗后第3天、第7天时的呼吸功能指标均好于对照组,血清炎性应激指标则均低于对照组,差异具有统计学意义(P<0.05)。结论:氨溴索可有效改善COPD急性发作患者呼吸功能,且对控制患者的炎性应激发挥着积极的作用。

Objective= To investigate the influence of ambroxol on respiratory function and inflam- matory stress of patients with chronic obstructive pulmonary disease at acute stage. Methods=Totally 70 patients with chronic obstructive pulmonary disease at acute stage were enrolled and randomly divided into control group（routine chronic obstructive pulmonary disease treatment group, n= 35 cases） and observa- tion group（routine treatment and ambroxol group, n= 35 cases）,then the respiratory function and inflam- matory stress indexes of two groups before the treatment and at third and seventh day after the treatment were detected and compared. Results= The respiratory function indexes of observation group at third and seventh day after the treatment were all better than those of control group, and the serum inflammatory stress indexes were all lower than those of control group （P all^0.05） showing significant difference be- tween the two groups. Oonclusion： The ambroxol can effectively improve the respiratory function of pa- tients with chronic obstructive pulmonary disease at acute stage, and it also plays an active role in impro- ving the inflammatory stress of patients.