妊娠糖尿病脂联素、炎性因子与胰岛素抵抗关系临床研究

Correlation between gestational diabetes,adiponectin,inflammatory factors and insulin resistance

目的:研究妊娠糖尿病(GDM)患者机体脂联素(ADP)及炎性因子水平与胰岛素抵抗(IR)的关系。方法:218例临床确诊的妊娠糖尿病患者为妊娠糖尿病组,127例同期健康孕妇为正常妊娠组,89例健康未孕妇女为对照组,比较3组脂联素、炎性因子C反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平及与胰岛素抵抗(IR)的关系。结果:妊娠糖尿病组、正常妊娠组及对照组脂联素、CRP、IL-6、TNF-α及胰岛素抵抗指数比较,差异均有统计学意义(P<0.05);妊娠妇女脂联素与炎性因子CRP、IL-6、TNF-α及胰岛素抵抗指数经spearman相关性分析均成负相关。结论:脂联素、炎性因子CRP、IL-6、TNF-α及胰岛素抵抗关系密切。

Objective. To study the correlation between adiponectin （ADP）, the levels of inflam- matory factors and insulin resistance （IR） in gestational diabetes mellitus （GDM） patients. Methods. To- tally 218 cases of clinically diagnosed gestational diabetes mellitus as diabetes were enrolled as gestational diabetes group, 127 healthy pregnant women as normal pregnancy group, 89 cases of healthy non-pregnant women as control group. Adiponectin, inflammatory factor （C reactive protein （CRP）, interleukin -6 （IL- 6）, tumor necrosis factor alpha （TNF ） levels and insulin resistance （IR） were compared among the three groups. Results： CRP, IL-6, adiponectin TNF- alpha and insulin resistance index were significant different among the three groups （P all0.05） showing significant difference. Adiponectin and inflammatory fac- tors CRP, IL-6, TNF- and insulin resistance index in pregnant women were negatively correlated. Con- clusion： Adiponectin, inflammatory factors CRP, IL-6, TNF- and insulin resistance were closely correla- ted.