摘要
目的:研究妊娠糖尿病(GDM)患者机体脂联素(ADP)及炎性因子水平与胰岛素抵抗(IR)的关系。方法:218例临床确诊的妊娠糖尿病患者为妊娠糖尿病组,127例同期健康孕妇为正常妊娠组,89例健康未孕妇女为对照组,比较3组脂联素、炎性因子C反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平及与胰岛素抵抗(IR)的关系。结果:妊娠糖尿病组、正常妊娠组及对照组脂联素、CRP、IL-6、TNF-α及胰岛素抵抗指数比较,差异均有统计学意义(P<0.05);妊娠妇女脂联素与炎性因子CRP、IL-6、TNF-α及胰岛素抵抗指数经spearman相关性分析均成负相关。结论:脂联素、炎性因子CRP、IL-6、TNF-α及胰岛素抵抗关系密切。
Objective. To study the correlation between adiponectin (ADP), the levels of inflam- matory factors and insulin resistance (IR) in gestational diabetes mellitus (GDM) patients. Methods. To- tally 218 cases of clinically diagnosed gestational diabetes mellitus as diabetes were enrolled as gestational diabetes group, 127 healthy pregnant women as normal pregnancy group, 89 cases of healthy non-pregnant women as control group. Adiponectin, inflammatory factor (C reactive protein (CRP), interleukin -6 (IL- 6), tumor necrosis factor alpha (TNF ) levels and insulin resistance (IR) were compared among the three groups. Results: CRP, IL-6, adiponectin TNF- alpha and insulin resistance index were significant different among the three groups (P all0.05) showing significant difference. Adiponectin and inflammatory fac- tors CRP, IL-6, TNF- and insulin resistance index in pregnant women were negatively correlated. Con- clusion: Adiponectin, inflammatory factors CRP, IL-6, TNF- and insulin resistance were closely correla- ted.
出处
《海南医学院学报》
CAS
2014年第4期525-527,共3页
Journal of Hainan Medical University
基金
深圳市宝安区科技计划项目(2013202)~~