辨证施治对鼻咽癌放疗副反应的治疗效果分析

Application of evidence-based medicine in the treatment of nasopharyngeal carcinoma radiotherapy

目的:探讨鼻咽癌患者放疗过程中,辅助中医辨证施治对鼻咽癌放疗副反应的影响。方法:选取我院2009年1月~2012年12月间收治的鼻咽癌首次放疗患者100例,随机分为观察组与对照组,观察组在首次放疗前进行辩证分型,从放疗第1天即根据辩证分型给予相应的中药汤剂内服,每天1剂,对照组单纯采用放射治疗,观察两组患者放疗过程中急性放射副反应症状积分及静、动态唾液流速的变化。结果:观察组放疗过程中2、3、4周急性放疗反应症状积分均显著低于对照组,静、动态唾液流速之和较对照组显著增高,组间比较差异均有统计学意义(P均<0.05)。结论:鼻咽癌患者放射治疗过程中,根据辩证分型配合相应的中药汤剂内服,可减轻患者放疗急性副反应的程度,有效改善临床症状,提患者放疗期的生活质量。

Objective- To study the influence of evidence-based medicine on treatment of nasopha- ryngeal carcinoma radiotherapy side effect. Methods： A total of 100 cases of nasopharyngeal carcinoma ra- diotherapy admitted from January 2009 to December 2012 were selected and randomly divided into observa- tion group and control group. Before radiotherapy, according to the evidence-based medicine classification, patients in the observation group were given corresponding Chinese medicine broth orally once a day; while patients in control group were given radiation therapy alone. Acute side effects, static and dynamic flow saliva and values change in the process of radiotherapy were observed and compared. Results, In observa tion group, during 2nd, 3rd, 4th weeks of radiation therapy, acute radiation reaction symptom score weresignificantly lower than the control group （P^0.05）. The static and dynamic saliva flow rate and value in observation group were significantly higher than the control group （P^0.05）. Oonclusion： Corresponding internal traditional Chinese broth according to evidence-based medicine classification can reduce acute side effects in radiation therapy, and effectively improve clinical symptoms and quality of life of patients.