子宫颈上皮内瘤样病变及鳞癌中p53与MDM2表达及相关性

The Expression and Relationship of p53,MDM2 in Cervical Intra epithelial Neoplasm and Cervical Squamous cell Carcinoma

目的 了解子宫颈上皮内瘤样病变 (CIN)及鳞癌 (SCC)中p5 3与MDM2表达及相关性。方法 用免疫组化SP法检测MDM2及p5 3蛋白在正常宫颈上皮、CIN、SCC中的表达 ,共 76例。结果 ①随着宫颈病变加重 ,MDM2、p5 3表达率均渐增高 ,二者在正常宫颈、CIN、SCC的表达率分别为 :MDM2的表达为 0、13 64 %、44 12 % ;p5 3的表达为 5 0 0 %、18 18%、47 0 6%。MDM2、p5 3在浸润癌组较CIN及正常宫颈组明显增高。②MDM2的表达与p5 3的聚积在统计学上未显示出有相关性。结论 MDM2、p5 3可能参与宫颈癌的发生、发展 ,对宫颈癌的诊断和治疗具有一定意义。

Objective To study the roles of MDM2 and p53 protein playing in the pathogenesis and development of cervical carcinoma.Methods The expression of MDM2 and p53 protein in normal cervical epithelium,cervical intra epithelial neoplasm(CIN) and invasive cervical squamous cell carcinoma(SCC)were detected with immunohistochemical SP methods in 76 cases.Results The expression rates of MDM2 and p53 were gradually increased with cervical lessions progress.The positive rates of MDM2 and p53 in normal cervical epithelium,CIN and invasive carcinoma were 0, 13.64% ,44.12%;5.00%,18.18%,47.06%,respectively.Conclusions 1 The positive rates of MDM2 and p53 in invasive cervical carcinoma group were obviously highier than those of normal cervical epithelium group and CIN group.2.The frequency of MDM2 did not show any correlation with the accumulation of p53 in statistics.The results suggest:MDM2 and p53 may be involved in the pathogenesis and development in cervical carcinoma,and be valualble in the diagnosis and treatment of cervical carcinoma.