上海“本地人”正常人群GSTT1和GSTM1基因型多态性研究

GENETIC POLYMORPHISM OF GLUTATHIONE S-TRANSFERASE T1 AND M1 IN SHANGHAI “INDIGENE” POPULATION

目的与方法 :以聚合酶链式反应 (PCR)技术对上海“本地人”正常人群GSTT1和GSTM1基因型多态性进行了研究。 结果 :上海“本地人”正常人群中GSTT1纯合缺损基因型和GSTM 1纯合缺损基因型的比率分别为 48 5 3 %和 5 4 40 % ,与上海市区正常人群中两种基因型的分布比率 (分别为 49 32 %和 48 86 % )没有显著差别。GSTT1-GSTM 1综合基因型 4种状态在两个人群中的分布频率也没有显著差别。结论 :GSTT1和GSTM1基因型多态性在同为上海地区居民的上海“本地人”正常人群和上海市区正常人群中呈均一分布。

Purpose and Methods: Population polymorphisms of the GSTT1 and M1 genes in the Shanghai “indi gene” group were evaluated using the PCR procedure. Results: In this group, the frequencies of GSTT1 null and GSTM1 null genotype are 48.53% and 54.40%, respectively. No significant differences were detected between urban individuals (49.32% and 48.86%, respectively) and an “indigene” group in suburb of Shanghai for GSTT1 and GSTM1 genotypes alone, as well as for four combined genotypes of GSTT1 and GSTM1. Conclusion: Between the “indigene” population in remote suburb and the urban population in downtown of Shanghai the genetic polymorphism distribution of GSTT1 and GSTM1 genes is proved to be homogenous.