可变钠与标准钠透析对血压及钠活性的影响

Influence of variablesodium and standardsodium dialysis on blood pressure and sodium activity

目的 :探讨可变钠碳酸氢盐与标准钠碳酸氢盐透析对透析患者血压的影响以及血清钠活性的变化。方法 :采用随机交叉对照研究 ,观察 31例慢性肾功能衰竭 (肾衰 )的血液透析患者分别采用可变钠透析 (VSD)和标准钠透析 (SSD)后血清钠活性的变化以及单次透析前后和 3个月后血压的改变。结果 :单次透析过程中SSD使血清钠活性逐渐升高 ,VSD则无显著影响。透析 3个月后 SSD使血压显著升高 ,原血压正常者尤为明显 ;而 VSD则不升高血压。结论 :VSD能减少透析性高血压的发生 ,其原因之一可能与改变了血清钠活性有关。

Objective:To investigate the changes in serum sodium activity and blood pressure during the process of variablesodium dialysis (VSD) and standardsodium dialysis (SSD).Methods:It was a random crossover study with controlled assignment order.Thirtyone chronic dialysis patients were selected to receive VSD and SSD respectively,and the change in serum sodium activity was observed.The change in blood pressure was also recorded during the single dialysis session as well as during each three months trial.Results:Serum sodium activity was gradually elevated during single SSD sessions and there was no change during single VSD sessions.After three months trial,blood pressure was significantly elevated in patients who received SSD,especially in those was nonhypertensive.Whereas,blood pressure wasn′t elevated in those who recieved VSD for three months.Conclusions:VSD can reduce the incidence of hypertension due to dialysis.One of causes maybe be that VSD can change serum sodium activity in chronic dialysis patients.