冠心宁注射液治疗心绞痛临床观察

Clinical Study of Guanxinning Injection in the Treatment of Angina Pectoris Patients

目的:观察冠心宁治疗冠心病心绞痛的疗效。方法:选取2010年11月-2012年11月在本院就诊的86例冠心病患者,其冠心病符合诊断标准。包括男57例,女29例。并且对这86例冠心病患者进行冠心宁注射液20 mL加入5%葡萄糖注射液或生理盐水250 mL中静脉滴注,1次/d,14 d为一疗程。一个疗程之后,患者病情平稳,观察以下指标:应用消心痛药物的量来控制症状在治疗前后有无改变;每天心绞痛发作的次数有无变化;血液流变学的变化;十二导连心电图ST段压低的总和。观察患者应用冠心宁注射剂治疗后的效果。结果:心绞痛症状缓解总有效率81.4%,治疗后心绞痛发作次数、缺血性ST段改善、血液流变学与治疗前相比均明显改善,差异均有统计学意义(P<0.01),在治疗过程中患者发生不良反应的例数明显降低,且症状都比较轻微。结论:冠心宁注射液治疗冠心病心绞痛有显著疗效,值得临床推广应用。

Objective：To observe the effect of Guanxinning injection on angina pectoris in CHD patients.Method：86 coronary heart disease patients were selected in our hospital November 2010 to November 2012,and they were accorded with the diagnostic criteria,57 cases were male and 29 cases were female.The patients with angina pectoris were treated by Guanxinning injection 20 mL one time daily.A period of treatment was 14 days.After a period of treatment,the patients were smoothly and observed the following indicators：whether the amount of use of isosorbide dinitrate drugs to control the changes of symptoms before and after treatment;whether the number of angina pectoris attack every day with or without changes;the change of blood rheology;Conventional 12-lead synchronous ST segment down.And the therapeutic effects of bolted ning injection in the treatment of angina pectoris were observed.Result：Total improvement rate was 81.4%in the angina pectoris patients.Frequency of angina pectoris attacking,ischemic ST segment and hemorheology changing after treatment were significantly improved,there were significant differences compared with before treatment（P〈0.01）.The cases of adverse reactions in patients with decreased obviously.Conclusion：The curative effect of Guanxinning injection for the angina pectoris patients is obvious,it is worthy of clinical application.