硫酸氨基葡萄糖与双氯芬酸钠缓释片治疗骨性关节炎40例临床疗效对比观察

The Comparative Observation of the Clinical Efficacy of Glucosamine Sulfate and Diclofenac Sodium Sustained-Release Tablets in the Treatment of Forty Cases with Osteoarthritis

目的:对比观察硫酸氨基葡萄糖与双氯芬酸钠缓释片在治疗骨性关节炎中的临床疗效。方法:选取2011年5月-2013年5月来本院就诊骨性关节炎的患者共40例,根据患者治疗方法不同分为A组和B组,A组患者采用硫酸氨基葡萄糖治疗,B组患者则采用氯芬酸钠缓释片治疗,治疗1个疗程后对比观察两组的疗效并记录胃肠道反应等副作用发生例数。结果:A组总有效率为95%,B组为90%,两组比较差异无统计学意义(P>0.05);A组副作用率(5%)明显低于B组(30%),两组比较差异有统计学意义(P<0.05)。结论:硫酸氨基葡萄糖和双氯芬酸钠缓释片对治疗骨性关节炎均有效,硫酸氨基葡萄糖的副作用更小,值得临床推广应用。

Objective：To comparatively observe the clinical efficacy of glucosamine sulfate and diclofenac sodium sustained-release tablets in the treatment of osteoarthritis. Method：40 patients of our hospital from May 2011 to May 2013 were randomly divided into two groups according to different treatment：the group A treated with the glucosamine sulfate and the group B treated with the diclofenac sodium sustained-release tablets. Efficacy was observed comparatively after a course of treatment and the number of cases of side effects such as gastrointestinal reactions was recorded. Result：The total effective rate of group A was 95%and the total effective rate of group B was 90%,and there was no difference between group A and group B in total effective rate（P〈0.05）. The side effect rate of group A（5%）was significantly lower than that of group B（30%）（P〈0.05）. Conclusion：Both the glucosamine sulfate and the diclofenac sodium sustained-release tablets for the treatment of osteoarthritis are valid. The side effect of glucosamine sulfate is smaller,worthy of clinical application.