分化抑制因子-1与头颈部肿瘤关系的研究进展

The Role of Inhibitors of Differentiation-1 in Head and Neck Neoplasm

近年研究表明,Id-1在人类多种头颈部恶性肿瘤诸如口腔鳞癌、鼻咽癌、喉癌、涎腺肿瘤等中过表达并通过多条信号通路推进细胞周期的演进,促进肿瘤细胞增殖、迁移、浸润,抑制细胞分化和诱导血管的发生,与肿瘤的预后密切相关,而且有望成为肿瘤治疗中的新靶点。

Inhibitor of Differentiation Protein 1（Id-1）as a new quasi-proto-oncogene,gets growing concern. In recent years,studies have shown the over expression of Id-1 in a variety of head and neck cancer in humans,such as oral squamous cell carcinoma,nasopharyngeal carcinoma, salivary gland tumors. Id-1 promotes the evolution of the cell cycle,tumor cell proliferation,migration,invasion,inhibition of cell differentiation and induction of vascular through several signaling pathways,which is closely related to the prognosis of tumor and therefore expected to become a new target for cancer therapy. This is a review of the research progress on the roles of Id-1 in tumorigenesis and its relative mechanisms.