老年患者医院感染与甲状腺功能变化的关系

Relationship between change of thyroid function of elderly patients and nosocomial infections

目的探讨高龄老年长期住院患者医院感染与甲状腺功能变化的关系,以降低甲状腺功能病态综合征的发生率。方法选择医院2012年1月-2013年1月住院治疗的30例患有慢性疾病老年患者为研究对象,观察患者医院感染前后出现的甲状腺功能变化,对患者甲状腺功能、高敏C-反应蛋白、血浆白蛋白、血白细胞等变化进行前后对照,并分析各项指标的变化趋势,所有数据经SPSS17.0统计软件进行分析。结果 30例患者发生医院感染后TT3、TT4、FT3均明显下降,数据比较差异有统计学意义(P<0.05),未出现游离T4下降。结论老年长期住院患者出现甲状腺功能病态综合征的发生率较高,医院感染会加重患者的病情,且病程长、易反复,恢复过程漫长。

OBJECTIVE To investigate the relationship between the nosocomiai infections in the elderly patients with long-term hospitalization duration and the change of thyroid function so as to reduce the incidence of thyroid function sick syndrome. METHODS Totally 30 elderly patients with chronic diseases, who were treated in the hospital from Jan 2012 to Jan 2013, were enrolled in the study, then the change of thyroid function was observed before and after the nosocomial infections occurred, the thyroid function, high-sensitivity C-reactive protein, plasma albumin, and white blood cells were compared before and after the infections occurred, the trends of changes of the indicators were analyzed, and the statistical analysis was performed with the use of SPSS17. 0 software. RESULTS The TT3, TT4, and FT of the 30 patients were significantly reduced after the nosocomial infections occurred, with statistical significance（P 0. 05）; the free T4 did not decrease. CONCLUSION The incidence of thyroid function sick syndrome is high in the elderly patients with long hospitalization duration the nosocomial infections may aggravate the illness, with disease course long, the illness prone to be recurrent, the recovery process lengthened.