产超广谱β-内酰胺酶大肠埃希菌的耐药性研究

STUDY ON DRUG RESISTANCE OF Escherichia coli PRODUCING EXTENDED-SPECTRUM β-LACTAMASE

目的研究临床标本检出产超广谱β-内酰胺酶大肠埃希菌的耐药特性,为临床科学选药提供依据。方法采用临床标本检测和细菌鉴定技术,对某医院临床送检标本病原学检测和细菌鉴定结果及耐药性进行调查与分析。结果分离自感染患者痰液和尿液中的产超广谱β-内酰胺酶大肠埃希菌对临床常用抗菌药物普遍耐药;对头孢哌酮、头孢呋辛钠和磷霉素的耐药率均为100%;仅对亚胺培南和美罗培南比较敏感。结论分离自不同标本中的产超广谱β-内酰胺酶大肠埃希菌对多数抗菌药耐药,仅对极少数抗菌药物比较敏感,提示临床要根据药敏试验结果选择抗菌药物。

Objective To study drug resistance of Escherichia coli producing extended - spectrum β - lactamases （ES-BLs） detected from clinical specimens, so as to provide basis for clinical scientific drug selection. Methods Clinical specimens detection and bacterial identification methods were used to investigate and analysis the etiological detection and i-dentification results and drug resistance of hospital clinical specimens. Results Escherichia coli producing extended - spectrum β -lactamases （ESBLs） were isolated from sputum and urine specimens of infectious patients are generally resist-ant to commonly used antimicrobial drugs, the resistance rate to cefoperazone, cefnroxime sodium and fosfomycin were all 100%, only sensitive to imipenem and meropenem. Conclusions Escherichia coli producing extended -spectrum β-lac-tamases （ESBLs） isolated from different specimens are resist to most antimicrobial drugs, only sensitive to small number of antimicrobial drugs, which means clinical antimicrobial drug selection should based on results of drug sensitivity test.