人软骨糖蛋白-39与支气管哮喘

Human cartilage glycoprotein 39 and bronchial asthma

人软骨糖蛋白-39（YKL-40）是一种新发现的炎症因子，属于哺乳动物18-糖基水解酶家族成员。既往研究表明，YKL-40与炎症和肿瘤有关。近年来研究显示，YKL-40可能参与了支气管哮喘（简称哮喘）的发生、发展，并且与气道重塑密切相关。YKL-40的生物学功能和作用尚不完全清楚，可能均参与了哮喘的炎症反应、气道高反应性、气道重塑的过程。YKL-40对于检测哮喘患者的辅助检查、严重程度、预后判断均有一定的意义。

Human cartilage glycoprotein 39 （YKL-40） is a newly discovered inflammatory cytokine, which belongs to the member of 18 glycosyl hydrolase of mammal family. Previous studies have indicated that YKL-40 is associated with the inflammation disease and tumors. Studies in recent years have suggested that YKL-40 may be involved in the occurrence of asthma and development, and is related to airway remodeling. The biological function and role of YKL-40 is not yet fully understood. It is possible involved in the inflammatory response of asthma, airway hyperresponsiveness, airway remodeling process. The detection of YKL-40 may have some significance in the aided diagnosis, asthma severity and predicting prognosis.