睡前中效胰岛素联合口服降糖药治疗2型糖尿病

Combination therapy with bedtime insulin and daytime oral hypoglycaemic agents in type 2 diabetic patients

目的 探讨睡前中效胰岛素联合口服降糖药治疗 2型糖尿病的临床意义。方法 90例经口服降糖药治疗失效的 2型糖尿病患者随机分成 2组 ,A组 (n =45 )应用中效胰岛素 2 2 :0 0皮下注射联合口服降糖药治疗 6个月 ,B组 (n =45 )单独应用胰岛素治疗 6个月 ,治疗前后 2组各临床及生化指标进行比较。结果 睡前中效胰岛素联合口服降糖药治疗能有效控制血糖 ,胰岛素用量少 ,血脂改善明显 ,胰岛功能恢复较好 ,体重增加不明显 ,低血糖发生率少。

Objective To explore the clinical value of the combination therapy with bedtime insulin and daytime oral hypoglycaemic agents(OHAS) in type 2 diabetic patients.Methods 90 cases of type 2 diabetic patients secondary failure to treatment with oral antidiabetic agents were randomly divided into two groups.45 patients in group A(n=45) were treated with bedtime (22:00) NPH insulin combined with OHAS for six months.45 patients in group B(n=45) were treated with insulin alone for six months.All the clinical and biochemical parameters were compared between the two guoups before and after treatment.Results The combination therapy with bedtime NPH insulin and OHAS can offer an advantage in terms of glyceamic control and lipid plasma profile,less insulin requirement,fewer symptomatic and biochemical cases of hypoglycemia,body weight remaining unchanged.Conclusion Conbination therapy with bedtime NPH insulin and OHAS offers an optimal therapy for type 2 diabetes secondary failure to treatment with OHAS.