摘要
目的 :探讨微血管密度 (MVD)在胃癌发展中的变化及血管第八因子相关抗原抗体 (F- )的表达水平的临床病理意义。方法 :用 F- 相关抗原抗体免疫组织化学染色 S- P法检测 5 6例胃癌手术切除标本 ,观察癌组织、癌旁及正常组织中微血管密度 ,分析其与胃癌的发展关系。结果 :微血管密度在癌组织为 40 .2 4± 13.6 ,癌旁为 2 5 .2 0± 10 .12 ,正常组织为 14.2 1± 4.2 5 (P<0 .0 5 ) ,有转移者与无转移者的微血管密度分别为 40 .17± 8.91和 19.2 1±10 .0 4(P<0 .0 1)。结论 :微血管的生长与胃癌的发展有关 ,除淋巴结转移、浸润深度 ,肿瘤分期具有预后意义外 ,胃癌组织中微血管密度也具有判断预后的价值。
Objective:To evulate the clinico-pathological signgnificance of intratumoral microvessel density(MVD) and F-Ⅷ expression in gastric cancer. Methods:MVD in 56 speciments resected from patients with gastric cancer was investigated by immunohistochemical staining with a monoclonal antibody against F-Ⅷ related antigen.Results:The means MVD was 40.24±13.6 in tumor , 25.20±10.12 in tumor-adjacent and 14.21±4.25 in normal tissue(P<0.05).The MVD in patients with cancer metastasis 40.17±8.91 which was significantly greater than in patients without cancer metastasis was 19.21±10.04(P<0.01 ).Conclusion:MVD was related to lymph node metastasis and bematogenous dissemination of gastric cancer.Beside lymph node metastasis, depth of invasion ,stage of tumor,MVD was also of prognostic significance. [
出处
《南通医学院学报》
2001年第1期27-28,共2页
ACTA Academiae Medicinae Nantong
