非洛地平缓释片对原发性高血压左室肥厚的影响

Effect of extended release felodipine tablet on left-ventricular hypertrophy of primary hypertension

目的观察非洛地平缓释片对高血压左室肥厚的逆转作用。方法应用动态血压及彩色多普勒超声心动图测定 2 6例高血压并左室肥厚患者口服非洛地平缓释片 (5～ 10mg/d) ,2 4周后血压及左室形态结构变化。结果治疗后血压明显下降 (P <0 0 1) ,舒张期室间隔厚度及左室后壁厚度 ,左室重量指数均明显减少 (P <0 0 1)。结论非洛地平缓释片不但能有效降低血压 ,而且能逆转左室肥厚。

Objective To observe the reversing effect of extended release felodipine tablet on left ventricular hypertrophy (LVH) in hyper tension. Methods The change of blood pressure (BP) and of left ventricular structure in 26 hypertensive patients with LVH before and after extended release felodipine tablet 5mg to 10mg per day treatment for 24 weeks were examined by Ambulatory blood pressure monitoring (ABPM), and doppler echocardiography. Results BP decreased apperently after extended release felodipine tablet treatment ( P <0.01). The interventricular septal thickness (IVST), the left ventricular posterior wall thickness (LVPWT) in diastole and left ventricular mass index (LVMI) were significantly reduced after extended release felodipine tablet treatment ( P <0.01). Conclusion Therapy with extended release felodipine tablet in hypertension can not only effectively decreas BP but also reverse LVH effectively.