氯沙坦对老年高血压左室肥厚及血管紧张素Ⅱ影响的临床观察

Clinical investigation of losartan effect of Left ventrioular hypertrophy and plasma angiotension Ⅱ in elderly hypertensive patients

目的 观察氯沙坦对老年高血压左室肥厚及血管紧张素 水平的影响。方法 选择 43例老年高血压伴左室肥厚病人 ,给予氯沙坦 50～ 1 0 0 mg/ d共 1 2～ 1 7个月的治疗 ,分别测定治疗前后左室重量指数 (LVMI)、左室功能及血浆血管紧张素 的水平。结果 与治疗前相比 ,LVMI明显减少 ,而血管紧张素 浓度有增加的趋势 ,但无统计学意义 (P>0 .0 5)。结论 氯沙坦在有效降压的同时可逆转左室肥厚 ,改善左室功能的作用 。

Objective To investigate the clinical effect of Losartan on left ventricular hypertorphy(LVH) and plasma angiotension Ⅱ in elderly hypertensive patients.Methods Forty three elderly hypertension patients accompanied with LVH were treated with Losartan,50～100 mg/d for twelve to seventeen months,left venfricular mass index(LVMI),left venfricular function and plasma Ang Ⅱ were estimated before and after treatment.Results After treatment with Losartan,LVMI was obviously reduced,while the levels of Ang Ⅱ slightly increased and there was no significant difference(P>005).Conclusions Losartan is effective in reducing hypertension,reversing LVA and improving the funtion,especially the left ventricular diastolic funtion.