老年慢性肝病患者血清ICDH、CHE的变化及临床意义

The changes and clinical significance of isocitrate dehydrogenase and cholinesterase in sera of the aged patients with chronic liver diseases

目的 探讨老年慢性肝病患者血清异柠檬酸脱氢酶 (ICDH)和胆碱脂酶 (CHE)的变化及临床意义。方法 对 70例老年慢性肝病患者及 54例健康老人血清中 ICDH和 CHE活性进行检测。结果 老年慢性肝病患者血清中 CHE活性明显低于正常对照组 ,且随病情加重降低更为明显 (P<0 .0 1 ) ;血清中 ICDH活性明显高于正常对照组 ,且随病情加重而升高更为明显 (P<0 .0 1 )。结论 ICDH和 CHE是反映肝实质细胞受损害及其合成代谢能力下降的敏感指标。检测 ICDH、CHE的变化可以反映肝病发展的程度 。

Objective To expflore the changes and clinical significance of isocitrate dehydrogenase(ICDH) and cholinesterase(CHE) in sera of aged patients with chronic liver diseases.Methods Examining ICDH and CHE in sera of 70 aged patients with chronic liver diseases and 54 normal cases as a control.Results The activities of ICDH and CHE in sera of aged patients with chronic liver diseases were much lower and higher respectively than those of control group ( P <0 01).Both of ICDH and CHE were negatively correlated ( P <0 05).Conclusions ICDH and CHE were sensitive markers of reflecting the damage and liver synthetic metabolism of liver cell.It was important to detect the ICDH and CHE for judging the degree of chronic liver diseases and treating effect.