子痫前期的临床预测因子研究

Research on clinical predictive factors of preeclampsia

目的 寻找子痫前期的临床预测因子.方法 回顾性分析60例子痫前期孕妇（子痫前期组）和1 974例正常孕妇（血压正常组）临床资料,子痫前期发病的独立危险因素采用多元Logistic回归分析.结果 血压正常组和子痫前期组年龄、体质量指数、妊娠史、职业、妊娠情况、新生儿性别、教育背景比较差异均无统计学意义（P＞0.05）;不孕史、既往子痫前期病史、参加产前保健（按计划完成）、合并高血压比较差异有统计学意义[4.3％（84/1 974）比48.3％（29/60）、2.1％（42/1 974）比70.0％（42/60）、98.2％（1 938/1 974）比80.0％（48/60）、5.0％（98/1 974）比45.0％（27/60）,P＜0.01或＜0.05].多元Logistic回归分析结果显示,子痫前期病史、合并高血压、不孕史为子痫前期发病的独立危险因素.结论 既往子痫前期病史、合并高血压、不孕史可以作为子痫前期的临床预测因子,有利于提前识别子痫前期高危孕妇.

Objective To find out the clinical predictive factors of preecfampsia.Methods A retrospective analysis was made on clinical data of 60 preec]ampsia （preeclampsia group） and 1 974 normal pregnant women （normal pregnant group）.Multiple factor Logistic regression analysis was used to determine independent risk factors of preeclampsia.Results There were no significant differences in age,body mass index,pregnant history,occupation,pregnant condition,newborn gender,education background between normal pregnant group and preeclampsia group （P ＞ 0.05）.There were significant differences in infertility history,preeclampsia history,antenatal care,combined with hypertention [4.3％ （84/1 974） vs.48.3％ （29/60）,2.1％（42/1 974） vs.70.0％（42/60）,98.2％（1 938/1 974） vs.80.0％（48/60）,5.0％（98/1 974） vs.45.0％ （27/60）,P ＜ 0.01 or ＜ 0.05].Multiple factor Logistic regression analysis showed that preeclampsia history,combined with hypertention,infertility history were the independent risk factors of preeclampsia.Conclusion The preeclampsia history,combined with hypertension and infertility history are the independent risk factors of preeclampsia which are available to identify patients with preeclampsia among high risk patients.