丙肝康对大鼠肝纤维化的抑制作用及对肾上腺皮质功能的影响

Inhibition to Fibrosis of Liver and Influence to Adrenal Cortex Function of Rat of Binggan(Hepatitis C)Kang

目的 :探讨丙肝康对牛血清白蛋白所致大鼠肝纤维化及肾上腺皮质分泌功能的影响。方法 :用牛血清白蛋白注射大鼠 ,形成肝纤维化。测定血清MAO、肝中胶原蛋白、尿中 17—OHCS及肾上腺中VitC含量。结果 :大鼠MAO、肝中胶原蛋白含量显著升高 (P<0 0 1) ,肾上腺中VitC含量显著增加 (P <0 .0 5) ,17—OHCS含量显著下降 (P <0 0 5)。丙肝康对MAO、胶原蛋白含量的升高有显著抑制作用 (P <0 0 1) ,对17—OHCS、VitC无明显影响 (P >0 0 5)。结论 :丙肝康有抑制肝纤维化作用 ,大鼠肝纤维化后 ,分泌糖皮质激素的功能低下 ,丙肝康对此无影响。说明 ,丙肝康并非通过影响肾上腺皮质功能产生抗肝纤维化作用。

Objective:to explore the influence of Binggan Kang to fibrosis of liver and adrenal cortex function of rat caused by serum albumin of ox.Methods:to use serum albumin of ox to inject rats to form liver fibrosis.To determine the contents of serum MAO,collagen in liver,17 OHCS in urine and Vitamin C in adrenal gland.Result:the contents of MAO of rat,collagen in liver rose significantly(P<0.01).The content of vitamin C in adrenal gland increased obviously.There was no significant influence to 17 OHCS and vitamin C(P>0.05).Conclusion:Binggan Kang had the function to inhibit liver fibrosis.After liver fibrosis,the function to secrete glucocorticoid hormone decreased,Binggan Kang had no influence to it.