高龄老年非酒精性脂肪肝与颈动脉粥样硬化的相关性及GGT的作用

Relationship between non-alcoholic fatty liver disease and carotid artery atherosclerosis in elderly patients and the function of GGT

目的探讨高龄老年人非酒精性脂肪肝(NAFLD)与颈动脉粥样硬化的相关性及谷氨酰胺转肽酶(GGT)在其中所起的作用。方法对62例高龄老年NAFLD患者(NAFLD组)和44例无脂肪肝患者(对照组)进行颈动脉彩超、血脂水平及GGT检查,比较2组患者一般临床资料、血脂水平、GGT、颈动脉内膜-中层厚度、颈动脉粥样斑块及颈动脉狭窄发生率的差异。结果 NAFLD组患者两种以上疾病患病率明显高于对照组。NAFLD组与对照组比较,血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇及GGT均明显升高,高密度脂蛋白胆固醇明显降低,颈动脉内膜-中层厚度明显增厚,差异有统计学意义(P<0.05)。但2组患者颈动脉在动脉硬化、斑块形成及动脉狭窄发生率差异无统计学意义(P<0.05)。结论患NAFLD的高龄老年患者动脉粥样硬化相关性心脑血管疾病及糖尿病的患病风险明显升高,这可能与其存在脂代谢紊乱及GGT升高密切相关。

Objective To examine the lipid levels, gamma - glutamyl ranspeptidase （GGT） and carotid atherosclerosis in eld- erly patients with non - alcoholic fatty liver disease （NAFLD）, and to investigate the relationship between non - alcoholic fatty liver dis- ease and carotid artery atherosclerosis in senile elderly patients and the function of GGT in it. Methods 62 elderly patients with NAFLD were selected as NAFLD group and 44 elderly patients without fatty liver were selected as control group. Both of them were examined by carotid Doppler uhrasongraphy, lipid levels and GGT. Comparing the difference of the general clinical data, lipid levels, GGT, carotid artery intima - media thickness, carotid artery plaque and carotid stenosis incidence between two groups. Results The incidence of the NAFLD group with more than two kinds of comordities was higher than that in control group. Compared with control group, the NAFLD group was higher in serum total cholesterol, triglycerides, low -density lipoprotein cholesterol and GGT, while it also has the characters that with lower high - density lipoprotein cholesterol and significantly thicker of the Carotid intima - media thickness. But there were no significant differences in the incidences of carotid atheroselerosis, plaque and stenosis between two groups. Conclusion NAFLD is closely related to early atherosclerosis. There is high risk of atheroselerosis related cardio - cerebrovascular diseases and diabetes in eld- erly patients with NAFLD. The reason is that may be closely related to lipid metabolism disorders and GGT rise.Objective To examine the lipid levels, gamma - glutamyl ranspeptidase （GGT） and carotid atherosclerosis in eld- erly patients with non - alcoholic fatty liver disease （NAFLD）, and to investigate the relationship between non - alcoholic fatty liver dis- ease and carotid artery atherosclerosis in senile elderly patients and the function of GGT in it. Methods 62 elderly patients with NAFLD were selected as NAFLD group and 44 elderly patients without fatty liver were selected as control group. Both of them were examined by carotid Doppler uhrasongraphy, lipid levels and GGT. Comparing the difference of the general clinical data, lipid levels, GGT, carotid artery intima - media thickness, carotid artery plaque and carotid stenosis incidence between two groups. Results The incidence of the NAFLD group with more than two kinds of comordities was higher than that in control group. Compared with control group, the NAFLD group was higher in serum total cholesterol, triglycerides, low -density lipoprotein cholesterol and GGT, while it also has the characters that with lower high - density lipoprotein cholesterol and significantly thicker of the Carotid intima - media thickness. But there were no significant differences in the incidences of carotid atheroselerosis, plaque and stenosis between two groups. Conclusion NAFLD is closely related to early atherosclerosis. There is high risk of atheroselerosis related cardio - cerebrovascular diseases and diabetes in eld- erly patients with NAFLD. The reason is that may be closely related to lipid metabolism disorders and GGT rise.