口服布洛芬预防早产儿颅内出血的前瞻性研究

Prospective study of ibuprofen to prevent premature infant with intracranial hemorrhage

目的探寻预防早产儿颅内出血安全有效的方法。方法将入选的早产儿336例按就诊顺序分为治疗组和对照组,治疗组于入院后12 h内口服布洛芬混悬液,通过头颅超声随诊颅内出血情况,同时观察肝肾功、血尿、凝血功能检查结果,观察需氧时间、恢复出生体重时间、机械通气、喂养不耐受、胃出血、坏死性小肠结肠炎(NEC)的发生情况。结果治疗组颅内出血的发生率较对照组明显降低(P<0.05),治疗组的需氧时间、恢复出生体重时间、机械通气例数较对照组明显减少(P<0.05);而治疗组与对照组在肝肾功、血尿、凝血功能检查,以及喂养不耐受、胃出血、NEC的发生情况比较差异无统计学意义(P>0.05)。结论口服布洛芬混悬液可以预防早产儿颅内出血,可以改善早产儿的临床症状,且没有明显副作用,可以推广应用。

Objective To investigate the effect of ibuprofen in preventing intracranial hemorrhage in premature infant. Methods 336 cases premature infant were randomly divided into treatment group and control group. Ibuprofen was used by mouth in 12hours after birth in treatment group and incidence of intracranial hemorrhage was observed between two groups. At the same time the oxygen need time, recover birth weight time, the cases of mechanical ventilation, the associated side effects were also observed. Results The incidence of intracranial hemorrhage in treatment group was lower than that in control group and there was a significant difference （ P 〈 0.05）. The oxygen need time, recover birth weight time, the cases of mechanical ventilation in treatment group was sig- nificantly lower than the control group （P 〈 0.05）. There was no difference in the associated side effects between the treatment group and the control group. Conclusion Ibuprofen can be used by mouth to prevent the incidence of intracranial hemorrhage in premature in- fant, to improve the early clinical symptoms and there was no associated side effects. This method can be used widely.Objective To investigate the effect of ibuprofen in preventing intracranial hemorrhage in premature infant. Methods 336 cases premature infant were randomly divided into treatment group and control group. Ibuprofen was used by mouth in 12hours after birth in treatment group and incidence of intracranial hemorrhage was observed between two groups. At the same time the oxygen need time, recover birth weight time, the cases of mechanical ventilation, the associated side effects were also observed. Results The incidence of intracranial hemorrhage in treatment group was lower than that in control group and there was a significant difference （ P 〈 0.05）. The oxygen need time, recover birth weight time, the cases of mechanical ventilation in treatment group was sig- nificantly lower than the control group （P 〈 0.05）. There was no difference in the associated side effects between the treatment group and the control group. Conclusion Ibuprofen can be used by mouth to prevent the incidence of intracranial hemorrhage in premature in- fant, to improve the early clinical symptoms and there was no associated side effects. This method can be used widely.