盐酸克林霉素低浓度DMF废水回收工艺改进

Clindamycin Hydrochloride Low Concentration DMF Wastewater Reclamation Technology Improvement

针对克林霉素合成中采用三光气氯化，产生大量低浓度DMF含盐废水，处理收率低、分离效果差、能耗高等问题，提出一种萃取、预处理、结合精馏的新工艺。确定了适合生产的工艺：萃取剂为氯仿，溶剂比2，温度30～40℃，回流比大于2：1，真空度为0．07～0．08MPa，DMF回收总收率80％～85％，含量大于98％，水分小于0．2％，达到新品标准，用于氯化工艺与新品无差异。

Clindamycin used for the synthesis of bis （triehloromethyl） carbonate chloride, resulting in a large number of low concentrations of DMF saline wastewater, treatment of low yield, poor separation efficiency, high energy consumption problem, an extraction, pretreatment, combined with new technology distillation. Determining a suitable production process ： chloroform extraction agent, the solvent ratio of 2 ： 1, the temperature of 30 - 40 ~C, a reflux ratio of greater than 2 - 1, the degree of vacuum of 0. 07 - 0. 08 MPa, DMF recovery yield of 80% - 85% of the total content of more than 98%, moisture less than 0. 2%, reaching new standards for technology and new chlorination no difference.