摘要
目的观察瓜蒌皮注射液对稳定型心绞痛痰瘀互结证患者的临床疗效以及对血管内皮功能的影响。方法将115例冠心病稳定型心绞痛痰瘀互结证患者随机分为对照组(56例)和观察组(59例)。两组均给予阿司匹林肠溶片、β受体阻滞剂、他汀类药物等常规治疗,观察组在此基础上加用瓜蒌皮注射液静脉输注12mL,每日1次,共14d。比较治疗前后临床疗效、心电图改善情况,以及一氧化氮(NO)、内皮素-1(ET-1)含量变化。结果观察组临床症状及心电图总有效率分别为86.44%及79.66%,对照组为66.07%及62.50%,两组比较有统计学意义(P<0.05);观察组中医证候有效率为59.32%,总有效率为84.75%,对照组分别为37.50%及64.29%,两组间比较有统计学意义(P<0.05);两组均未发生严重不良反应。与对照组相比,观察组能明显改善一氧化氮及内皮素-1水平(P<0.05)。结论瓜蒌皮注射液治疗稳定型心绞痛痰瘀互结证患者疗效可靠,并可以明显改善ET-1及NO水平。
Objective The aim is to observe the clinic treatment effect of pericarpium trichosanthis injection(PTI) in patients with stable angina pectoris complicated with phlegm stasis syndrome,and the influence to vascular endothelial function. Methods One hundred and fifteen patients with stable angina pectoris complicated with phlegm - stasis syndrome were divided into two groups randomly, 56 patients for control group, and 59 patients for observation group. The two group patients were given the same treatment with aspirin, β - blocker, statins, etc. On this basis the observation group was given PTI at a dose of 12 mL per day for venous dripping for 14 days. The clinical effects,the levels of nitric oxide (NO) and endothelin- 1 (ET- 1) were analyzed before and after the treatment. Results The clinic and electrocardiogram total efficiency was 86.44%, 79.66% in observation group and 66.07%,62.50% in control group, respectively. The clinic and efficiency in observation group was higher than that in control group(P〈0.05). The traditional Chinese medicine(TCM) syndrome efficiency and total efficiency was 59.32% ,84.75% in observation group,and 37.50%,64. 29% in control group respectively. The TCM syndrome efficiency of observation group was better than that of control group(P〈0.05). There was no severe adverse reaction in the both groups(P〈0.05). Compared with the control group, the levels of NO and ET- 1 were improved in observation group (P〈0.05). Conclusion PTI has reliable curative effect for the treatment of stable angina pectoris with phlegmstasis syndrome,and can obviously improve the levels of NO and ET- 1 in patients.
出处
《中西医结合心脑血管病杂志》
2014年第1期3-5,共3页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词
稳定型心绞痛
痰瘀互结
瓜蒌皮注射液
一氧化氮
内皮素-1
stable angina pectoris
phlegm - stasis syndrome
pericarpium trichosanthis injection
nitric oxide
endothelin - 1