泻肝安神方改善广泛性焦虑症患者生活质量的观察

Effect of Xiegan Anshen Prescription on the Quality of Life in Patients with Generalized Anxiety Disorder

目的观察泻肝安神方改善广泛性焦虑症(GAD)肝郁化火证患者中文版健康调查简易量表(SF-36)生活质量评分情况及SF-36各维度与焦虑的相关性分析。方法将130例GAD患者随机分为治疗组和对照组,治疗组100例,对照组30例,分别口服泻肝安神方和帕罗西汀治疗,疗程均为6周。以SF-36、汉密顿焦虑量表(HAMA)对两组GAD肝郁化火证患者治疗前后生活质量水平及焦虑程度进行评价。结果两组在治疗前后SF-36各条目间比较均无统计学意义(P>0.05),但两组在治疗6周后与本组治疗前SF-36各维度比较有统计学意义(P<0.01)。两组在治疗前后SF-36各维度中除生理机能外,其余各维度值与HAMA总分及因子分呈显著负相关(P<0.05)。结论泻肝安神方在改善GAD肝郁化火证患者的生活质量水平方面与帕罗西汀相当,且患者的焦虑情绪对其生活质量影响较大,即患者的焦虑情绪越严重其生活质量水平越低。

Objective To investigate Xiegan Anshen prescription （XAP） on quality of life in patients with generalized anxiety disorder （GAD）. Methods One hundred and thirty patients with GAD were divided into two groups：The control group（n--30）treated with paroxetine hydrochloride,and treatment group（n= 100） treated with XAP. The quality of life level and the degree of anxiety were evaluated with 36 - item short - form Health Survey （SF - 36） and Hamilton rating scale for anxiety（HAMA）. Results After 6 weeks of treatment,the scores of SF - 36 in two groups were significantly higher than those before treatment （P〈0.01）. Except physical functioning （PF） domain,the SF- 36 of GAD patients in both groups before and after treating was significantly associated with HAMA（P〈0. 05）. Conclusion XAP can improve the quality of life in patients with GAD,and the quality of life is closely relat- ed to their anxiety state in patients with GAD.