胚泡着床窗口的分子调控

Molecular Control of Implantation Window of Blastocyst

着床窗口是指当胚胎发育到胚泡阶段时 ,子宫也增殖和分化到可接受状态 ,二者相互作用使胚泡着床的短暂时间 .雌激素和孕酮是该过程的综合调控分子 ,它们通过多种局部信号分子的介导 ,使子宫中的各种细胞类型增殖、分化 ,为着床窗口的开放做出相互协调的反应 .子宫与胚胎在着床窗口通过前列腺素、组织胺、降钙素、多种细胞因子和生长因子的旁分泌作用进行分子对话 ,使胚泡滋养层与子宫内膜上皮发生附着反应 .着床窗口一旦开放 ,即自动向非接受态转化 .

Implantation window is the transient period when the embryos develop into blastocysts and the uterus differentiates into the receptive state synchronically. Estrogen and progesterone are the comprehensive regulating molecules during this process. They influence the proliferation and differentiation of multiple cell types in the uterus through the modulation of various local-signaling molecules. Uterus and blastocyst interact by the paracrine effects of prostaglandin, histamine, calcitonin, cytokines and growth factors at implantation window. This molecular cross-talk modulates the interaction between trophectoderm and uterine luminal epithelium. Once the implantation window is open, it then switches into unreceptive state spontaneously.