哺乳动物防御素的研究进展及其应用前景

Advances in the Research and Application of Mammal Defensin

防御素是生物界广泛存在的一类具微生物抗性的低分子短肽 ,其中哺乳动物防御素的抗性谱最为广泛 ,具有很高的应用潜力 .概述了哺乳动物防御素的组成分布、立体结构、基因表达调控、抗菌谱等的国内外研究进展 ,并展望了其在医学和植物抗病基因工程中的应用前景 .

Defensin is a kind of antimicrobiol and cytotoxic peptides which have been found in a large range of living organisms. The mammal defensins have the most wide range antimicrobiol spectrum. The distribution, structure, gene expression regulation of mammal defensins in China and abroad were summarized. Its application on medicine and plant resistant gene engineering were prospected.