DNA损伤监测及修复相关酶与细胞衰老

Cell Senescence and the Enzyme System for Surveillance and Repair of DNA Damage

衰老是细胞的重要生命现象之一 ,衰老假说之一认为细胞中残留DNA损伤的积累可加速细胞的衰老 .因此 ,细胞内DNA损伤监测及修复系统的正常运行与细胞衰老调控密切相关 ,DNA损伤监测及修复相关酶如PARP、DNA PK、ATM、p5 3等在细胞衰老中的调控作用日益受到广泛关注 .研究这些蛋白质分子间的相互作用及其在细胞衰老过程中的调控功能 ,有利于揭示DNA损伤应激、损伤修复调控与细胞衰老之间的内在联系 ,为抗衰老研究及从衰老角度治疗肿瘤提供新的思路 .

Senescence is one of the most important phenomena in cells life. It is hold by one of hypothesis for cell senescence that residue DNA damages of a cell will accelerate its senescence. The normal function of surveillance and repair system for DNA damage is highly related with the senescence regulation of a cell. As a result, research of senescence regulation role of enzymes related for surveillance and repair of DNA damage, such as PARP, DNA PK, ATM, p53, etc., will discover the inner relation between stress response of cell to DNA damage, regulation of DNA damage repair and cell senescence. That may be helpful for research of anti aging and treatment of tumor by regulation of senescence of tumor cells.