比较5种血清肿瘤标志物联合检测对肺癌诊断和治疗的临床效果

Comparison of 5 Kinds of Serum Tumor Markers in the Clinical Effect of Combined Detection for the Diagnosis and Treatment of Lung Cancer

目的:探讨分析5种血清肿瘤标志物联合检测对肺癌诊断和治疗的临床效果。方法:通过酶联免疫法对50例肺癌患者和50例肺良性疾病患者的血清肿瘤标志物进行检测,主要检测的项目为血清神经元特异性烯醇化酶(NSE)、细胞角蛋白19片段(Cy-fra21-1)、糖类癌抗原199(CA199)、糖类抗原125(CAl25)和癌胚抗原(CEA),进而探讨分析5种血清肿瘤标志物联合检测对肺癌诊断和治疗的临床效果。结果:肺癌患者5种血清肿瘤标志物的水平均明显高于肺良性疾病患者的检测水平,比较差异均有统计学意义(P<0.05)。其中NSE在小细胞肺癌中高表达,CAl25在腺癌中高表达,不同肺癌类型患者的CA199、CAl25、NSE三种血清肿瘤标志物的阳性率比较差异均有统计学意义(P<0.05),而CEA和Cy-fra21-1两种血清肿瘤标志物的阳性率比较差异无统计学意义(P>0.05),不同病理类型的肺癌患者的CA123和Cy-fra21-1两种检测水平比较差异均有统计学意义(P<0.05),而其余三种肿瘤标志物检测水平比较差异均无统计学意义(P>0.05)。而5种肿瘤标志物联合检测的灵敏度、准确度和特异度分别为92.0%、89.0%、88.0%,均明显优于单个肿瘤标志物的检测,比较差异均有统计学意义(P<0.05)。结论:血清肿瘤标志物的联合检测可显著提高肺癌患者的灵敏度和准确度,对肺癌患者的诊断和治疗有显著的临床意义。

Objective：To analyze 5 kinds of serum tumor markers for clinical effect of combined detection for the diagnosis and treatment of lung cancer.Method：By enzyme-linked immunoassay for 50 patients with lung cancer and 50 patients with lung benign disease serum tumor markers were detected,the main test items of serum neuron specific enolization enzyme（NSE）and cytokeratin 19 fragment（Cy-fra21-1）,carbohydrate antigen 199 （CA199）,carbohydrate antigen 125（CAl25）and carcinoembryonic antigen（CEA）,and 5 kinds of serum tumor markers for clinical effect of combined detection for the diagnosis and treatment of lung cancer were investigated and analyzed.Result：The levels of five kinds of serum tumor markers in patients with lung cancer were higher than the detection level of patients with lung benign disease,the differences were statistically significant（P0.05）,two level detection of CA123 and Cy-fra21-1 in patients with lung cancer of different pathological type,the differences were statistically significant（P0.05）.The five kinds of tumor markers combined detection sensitivity,accuracy and specific degree 92.0%,89.0%and 88.0%respectively,were superior to single detection of tumor markers,the differences were statistically significant（P〈0.05）. Conclusion：The serum tumor markers combined detection can significantly improve the sensitivity and accuracy of the patients with lung cancer,the diagnosis and treatment of patients with lung cancer have significant clinical significance.