探讨不同病原体致小儿肺炎中的降钙素原改变

Discuss on Change of Serum Procalcitonin in Infantile Pneumonia Caused by Different Pathogen

目的:探讨不同病原体致小儿肺炎中血清降钙素原(PCT)的改变和在鉴别细菌性与病毒性感染小儿肺炎的预测价值。方法:对全部的73例小儿肺炎患者进行PCT、C-反应蛋白(CRP)及外周血白细胞计数(WBC)检查,并比较各指标在细菌性和病毒感染性的小儿肺炎中的敏感性和特异性的差异。结果:在各类型感染性肺炎患儿血清中的PCT、CRP、WBC数值比较中以PCT≥1μg/L为诊断病毒性感染和细菌性感染的敏感性和特异性最高,若以PCT≥1μg/L为阳性阈值,则细菌感染敏感性为81.8%,特异性为92.5%。结论:PCT作为鉴别细菌性和病毒性感染的特异性和敏感性更高,优于CRP和WBC。

Objective：To discuss the change of serum procalcitonin（PCT）in infantile pneumonia caused by different pathogen and predictive value of PCT in discerning between bacterial infection and viral infection. Method：PCT,C-reactive protein（CRP）and peripheral white blood cell count （WBC）of 73 patients with infantile pneumonia were examined. The difference of sensitivity and specificity in these indexes between bacterial infection and viral infection were compared. Result：Among PCT,CRP,and WBC,PCT≥1μg/L had the highest sensitivity and specificity in diagnosis of bacterial infection and viral infection. If PCT≥1μg/L were regarded as positive threshold value,the sensitivity of bacterial infection was 81.8%,and specificity was 92.5%. Conclusion：PCT has higher specificity and sensitivity than CRP and WBC in discerning bacterial infection and viral infection.