持续血液净化在肾内科治疗中的作用

The Role of Continuous Blood Purification in the Renal Medical Treatment

目的:探讨持续血液净化(BP)在肾内科治疗中的疗效。方法:选择116例ARF患者,按照随机数字表法将其均分为BP组和对照组。BP组接受持续BP治疗;对照组接受常规治疗。结果:116例ARF患者病因:68.1%(79例)为肾前性;16.4%(19例)为肾性;6.9%(8例)为肾后性;其他8.6%(10例)。其首要疾病诱发因素为感染,占29.3%(34例)。BP组总有效率高达87.9%,对照组为51.7%,两组比较差异有统计学意义(P<0.01)。且BP组死亡率显著低于对照组,两组比较差异有统计学意义(P<0.05)。BP组BUN、Scr各项生化指标均明显低于对照组,两组比较差异有统计学意义(P<0.05)。BP组患者血Na+、血K+及血Ca2+等电解质水平均明显获得改善,且均显著优于对照组,两组比较差异均有统计学意义(P<0.05)。结论:ARF的主要病因是肾前性因素,主要诱发因素是感染。给予ARF患者持续BP治疗,可以提高治疗效果,降低患者死亡率,同时可以明显降低血BUN、Scr等指标,改善患者血电解质水平,有益于缓解ARF病情和严重程度,有助于ARF患者尽快恢复。

Objective：To explore the role of continuous blood purification in the renal medical treatment.Method：116 patients with ARF were selected and divided into BP group and control group. BP groups：58 patients were treated with continuous BP.Control group：58 patients were treated with conventional therapy.Result：The etiologies of 116 patients with ARF：116 cases（68.1%）were prerenal;19 cases（16.4%）were renal,8 cases （6.9%）were postrenal,others were 8.6%（10 cases）. Its primary disease risk factors were infection,accounted for 29.3%（34 cases）.Efficiency of BP group was as high as 87.9%,and was obviously higher than that of control group（P〈0.01）,and the mortality rate was significantly lower than control group（P〈0.05）. BUN,Scr and biochemical indicators of 58 patients in BP group were significantly lower than the control group（P〈0.05）. Blood Na＋, K＋and Ca2＋blood,blood electrolyte levels of patients in BP group significantly improved,and were significantly better than the control group（P〈0.05）. Conclusion：The main etiologies of patients with ARF are prerenal,and the main inducing factor is infection. Continuous blood purification treating patients with ARF,can improve the effect of treatment,reduce mortality of patients,and also can significantly decrease the blood BUN,Scr and other indicators, improve the patients’ blood electrolyte level. It is conducive to ease the ARF illness and severity,and it can help ARF patients resume as soon as possible.