脾氨肽治疗免疫功能低下的疗效观察

Observation of Spleen Aminopeptide Oral Lyophilized Powder Treatment of Immunocompromised

目的:探讨使用脾氨肽口服冻干粉治疗小儿支气管哮喘的临床疗效以及对患儿免疫系统的影响。方法:选取2008年3月-2010年3月在本院接受治疗的86例支气管哮喘患儿,按照随即数字表法将其分为试验组和对照组各43例,对照组给予支气管哮喘常规基础治疗,试验组在对照组的治疗方案基础上采用脾氨肽口服冻干粉治疗,比较两组患儿的临床疗效及治疗前后的免疫球蛋白水平。结果:试验组患儿总有效率97.67%明显高于对照组的58.14%,比较差异有统计学意义(P<0.05)。试验组患儿治疗前、后的IgM水平比较差异无统计学意义(P>0.05),但治疗后的IgA以及IgG水平均明显高于治疗前与对照组,差异均有统计学意义(P<0.05)。而对照组患儿治疗前、后的免疫球蛋白水平比较差异均无统计学意义(P>0.05)。结论:脾氨肽口服冻干粉使用安全、方便,可有效地对患儿免疫功能低下进行调节,并对小儿哮喘有着很好的临床疗效。

Objective：To discuss the clinical effect of using spleen Aminopeptide Oral Lyophilized Powder in treatment of children with bronchial asthma and the effect on children＇s immune system.Method：86 cases of bronchial asthma were selected from March 2008 to March 2010 in our hospital, they were randomly divided into the test group and the control group,43 cases in each group.The control group was given conventional therapy of bronchial asthma,the test group on the basis of the control group was given Spleen Aminopeptide Oral Lyophilized Powder treatment.Immunoglobulin levels before and after treatment and the clinical curative effect of the two groups were compared.Result：The total efficiency of the test group was 97.67%,it was significantly higher than 58.14%of the control group,the difference was statistically significant（P0.05）,but after treatment,IgA and IgG levels were significantly higher than that before treatment and the control group,the differences were statistically significant（P0.05）.Conclusion：Spleen Aminopeptide Oral Lyophilized Powder of safe and convenient use,can effectively regulate immune function in children with low,and has a good clinical efficacy in children with asthma.