苦参苍术口服液急性毒性研究

Acute Toxicity Test of Kushencangshu Oral Liquid

为了考察苦参苍术口服液的安全性，按《兽药注册资料汇编》的要求，选用小白鼠进行了急性毒性试验。结果显示，苦参苍术口服液灌胃给药的LD50为20．51mL／kg，相当于生药量68．91mL／kg，可判断苦参苍术口服液为小毒。95％可信限（可信区间）范围为16．37-25．90mL／kg，相当于禽临床用量的27．3～43．2倍，说明苦参苍术口服液临床使用安全。

In order to evahmte the actue toxicity of Kusheneangshu oral liquid, the experiment was conducted in accordance with acute toxicity req of Kushencangshu oral liquid was uirements in compilation of veterinary drug registration data. studied in mice in this experimenl, the toxicity of Kushenc was demonstrated by the minimal lethal dose and the LD50 of mice. The resuhs showed th Kushencangshu sonous; lhe The acute t angshu oral at the LD50 oxicity liquid of the was 20.51 mL/kg, equal to 68.91 g/kg of the crude drug every （lay, it had light poi- dose ranged between 16.37 and 25.9 mL/kg, which was equivalent to from 27.3 to 43.2 times of daily dosage of pouh：ry. Kushencangshu oral liquid was relatively safe in clinical appli