RF、抗RA33、抗CCP及ESR联合检测对早期类风湿关节炎的诊断意义

The Value of Combined Detection of Serum RF, Anti-RA33, Anti-CCP and ESR in the Diagnosis of Early Rheumatoid Arthritis

目的探讨联合检测RF、抗RA33、抗CCP及ESR在早期类风湿关节炎中的诊断意义。方法将130例早期RA患者作为观察组,120名健康人作为对照者。两组均采用ELISA。检测抗RA33抗体和抗CCP抗体,采用生化仪检测RF,ESR测定采用魏氏法。结果 130例早期RA患者中,RF阳性92例,占70.7%;抗RA33抗体阳性15例,占11.5%;抗CCP抗体阳性77例,占59.2%;ESR阳性53例,占40.7%。对照组RF阳性2例,占1.6%;抗RA33抗体阳性1例,占0.8%;抗CCP抗体阳性1例,占0.8%;ESR阳性5例,占4.2%。结论联合检测RF、抗RA33、抗CCP及ESR对类风湿关节炎的诊断和治疗具有重要意义。

Objective To explore the value of combined detection of serum RF, anti-RA33, anti-CCP and ESR in the diagnosis of early rheumatoid arthritis. Methods 130 cases of early RA patients were selected as the observation group and 120 healthy people were selected as controls. In the two groups, anti-RA33 and anti-CCP were detected by ELISA method, RF was detected by bio- chemical instrument and ESR was detected by Westergren method. Results Of the 130 cases of early RA patients in the observa- tion group, RF was positive in 92 cases, accounting for 70.7%; Anti-RA33 was positive in 15 cases, accounting for 11.5%; Anti- CCP was positive in 77 cases, accounting for 59.2%; ESR was positive in 53 cases, accounting for 40.7%. In the control group, RF was positive in 2 cases, accounting for 1.6%; Anti-RA33 was positive in 1 case, accounting for 0.8%, Anti-CCP was positive in 1 case, accounting for 0.8%; The ESR was positive in 5 cases, accounting for 4.2%. Conclusion The combined detection of RF, an- ti-RA33, anti-CCP and ESR is significant to the diagnosis of early rheumatoid arthritis.