摘要
骨质疏松症是一种骨退行性病变,其发生主要与骨吸收和骨重建失衡有关。根据骨质疏松症的发病机制的不同,临床治疗药物主要分为基本补充剂、抗骨吸收药物和促骨形成药物。钙剂和维生素D是药物治疗的基础;抗骨吸收药物包括双磷酸盐、雌激素及其受体调节剂、降钙素;甲状旁腺激素为促骨形成药物;锶盐、维生素K2等兼有抗骨吸收和促骨形成的作用。特殊人群以及不同类型的骨质疏松症治疗要注意药物的适用性和针对性。
Osteoporosis is a disease of bone degeneration resulted from the imbalance of bone resorption and bone formation. Clinical medicines are divided into three categories according to the pathogenesis：basie supplements, anti-resorptive agents and bone formation-accelerating agents. Calcium and vitamin D are basic supplements, anti-resorptive agents include bisphosphonate, HRT/SERMs and calcitonin. PTH is the bone- forming agent while strunium ranelate and vitamin K2 have both anti-resorptive and bone-forming effects. Drugs treatment should be more applicable and specific when administered to different types of osteoporosis.
出处
《医学综述》
2014年第1期105-109,共5页
Medical Recapitulate
关键词
骨质疏松症
治疗
药物
抗骨吸收剂
促骨形成剂
Osteoporosis
Therapy
Drug
Anti-resorptive agents
Bone formation-accelerating agents
