氮杂Wittig反应的最近进展

Recent Advances in Aza-Wittig Reaction

综述了最近几年氮杂Wittig反应的研究进展 ,包括分子间氮杂Wittig反应、分子内氮杂Wittig反应及串联的氮杂Wittig反应。讨论了氮杂Wittig反应在一些含氮杂环、稠杂环及天然产物合成中的应用。

Recent advances in aza-Wittig reaction, including intermolecular, intramolecular and tandem ones, are reviewed. The application of the aza-Wittig reactions in synthesis of some N-heterocycles, fused heterocycles and natural products are also discussed. Some N-containing compounds not easily accessible by other methods were prepared by intermolecular aza-Wittig reactions under mild neutral conditions. The efficient intramolecular aza-Wittig reaction was also successively utilized in synthesis of five to eight-membered heterocycles, including some optically active natural compounds. Many heterocycles, fused heterocycles and natural compounds were prepared via the versatile tandem aza-Wittig reaction, such as tandem aza-Wittig/heterocumulene-mediated annulation, three component tandem aza-Wittig reaction, tandem aza-Wittig/electrocyclic ring closure, tandem aza-Wittig/hetero-Diels-Alder closure and tandem aza-Wittig reaction utilizing bis-iminophosphorane.