两种新木脂素(±)-Eusiderin E和(±)-Eusiderin F的全合成研究

Total Synthesis of Two Neolignans for (±)-Eusiderin E and (±)-Eusiderin F

以焦性没食子酸为原料 ,以克来森重排为关键步骤 ,首次合成了天然产物 (± ) -Eusiderin E和 (± ) -Eusiderin

?-Eusiderin E and (±)-Eusiderin F, two neolignans, were first synthesized from pyrogallol, in which route the Claisen Rearrangement was used to afford four C6_C3 units 2,6-dimethoxy-3-allyl-phenol(5), 1-(3,5-dimethoxy-4-hydroxy-phenol)propene(6), 3-methoxy-5-allyl-1,2-benzene-diol(9), 1-(5-methoxy-3,4-dihydroxy-phenol)propene(10).