硒联合甲巯咪唑治疗Graves'病患者的临床研究

Clinical research on the selenium combination with methimazole in treatment of Graves' disease

目的评价硒联合甲巯咪唑治疗Graves'病(GD)患者的疗效。方法 70例首次确诊Graves'病患者随机分为对照组和治疗组。测定该两组患者治疗前及治疗后8周及6月后TT3、TT4、FT3、FT4及TSH水平。结果治疗组与对照组同期比较,治疗后8周及治疗后6月,治疗组血清TT3、TT4、FT3、FT4水平明显低于对照组(P均<0.05),血清TSH水平明显高于对照组(P均<0.05)。结论本研究显示硒联合甲巯咪唑能明显改善Graves'病患者血清甲状腺激素水平。

Objective To evaluate the efficacy of the selenium combination with methimazole in treatment of Graves＇ disease. Methods 70 patients were randomly divided into two groups. The levels of thyroid function were measured before and after the treatment of eight weeks and six months. Results The levels of serum TT3, TT4, FT3, FT4 in the treatment group were significantly lower （P〈0.05） as compared to the control group. Conclusions Our results suggest that selenium combination with methimazole can greatly improve the levels of thyroid function of Graves＇ disease.