早期肠内营养对急性重症胰腺炎预后的影响

The effect of early enteral nutrition on the prognosis of severe acute pancreatitis

目的探讨早期肠内营养(EN)对急性重症胰腺炎(SAP)预后的影响。方法将58例SAP患者随机分为EN组(试验组,n=30)和经中心静脉全肠外营养(TPN)组(对照组,n=28),试验组经鼻空肠管(远端放置于Treitz韧带下)行营养支持,对照组行TPN支持,观察两组在并发症发生率、感染率、病死率、住院时间及住院费用的差异。结果试验组均能耐受EN,且并发症发生率、感染率、住院时间及住院费用均明显低于对照组,差异有统计学意义(P<0.05);试验组患者的病死率低于对照组,但差异无统计学意义(P>0.05)。结论 EN支持治疗可以改善SAP患者的营养状况,降低并发症发生率、感染率、住院时间及住院费用。

Objective To investigate the effect of early enteral nutrition on prognosis of severe acute pancreatitis （SAP） .Methods Fifty-eight patients with SAP were randomly divided into early enteral nutrition group （experimental group ,n=30） and total par-enteral nutrition（TPN） group（control group ,n=28） .The experimental group was feed by Nose-jejunum nutrition tube and the con-trol group were supported with TPN through central vena .Compared the differences in complication incidence rate ,infection rate , mortality rate ,length of hospital stay and costs between two groups .Results The incidence rate of complications ,infection rate , length of hospital stay and hospital costs in experimental group were lower than control group ,the difference was statistically sig-nificant（P〈0 .05） .The mortality in experimental group was lower than control group ,but the difference was not statistically sig-nificant（P〉0 .05） .Conclusion Early enteral nutrition support therapy can improve the nutritional status of patients with SAP ,re-duce the incidence of complications ,infection ,length of hospital stay and hospital costs .