显微手术对87例脑胶质瘤患者认知、生活能力及血流灌注和神经肽水平的影响

Effects of microsurgical technique treatment on acknowledge ability,activities of daily living, cortex blood perfusion and neuropeptide levels of brain glioma patients

目的研究显微手术治疗对于脑胶质瘤患者认知、生活能力、皮层血流灌注和脑脊液神经肽类物质水平的影响。方法采用显微手术和传统手术分别治疗87例脑胶质瘤患者,采用长谷川智能量表(HDS)、简易精神状态量表(MMSE)和日常生活能力量表(ADL)评估患者认知、生活能力,并检测患者术后皮层血流灌注情况和脑脊液精氨酸加压素(AVP)、催产素(OT)、β-内啡肽(β-EP)、生长抑素(SS)和神经降压素(NT)的水平。结果显微手术患者的HDS、MMSE和ADL量表评分均显著优于传统手术,且皮层血流灌注丰富,差异均有统计学意义(P<0.05);脑脊液中5种神经肽类物质水平也高于传统手术患者,差异有统计学意义(P<0.05)。结论显微手术能够改善脑胶质瘤患者认知、生活能力,改善脑血流灌注,恢复脑脊液神经肽水平。

Objective To explore the effects of microsurgical technique treatment on acknowledge ability ,activities of daily living ,cortex blood perfusion and neuropeptide levels of brain glioma patients .Methods Microsurgical technique treatment and tradi-tional operation were given to 87 brain glioma patients ,respectively .The acknowledge ability and activities of daily living were measured by HDS ,MMSE and ADL ;the cortex blood perfusion were revealed by PET ,and the neuropeptide levels including argi-nine vasopressin ,oxytocin ,β-endorphin ,somatostatin and neurotensin of patients from two different surgical groups were compared . Results As compared with the traditional operation ,the acknowledge ability and activities of daily living of patients from microsur-gical treatment group were significantly improved（P〈0 .05） ,the cortex blood perfusion were statistically increased （P〈0 .05） and the levels of five kinds of neuropeptide were all profoundly increased （P〈 0 .05） .Conclusion Microsurgical technique treatment could improve the acknowledge ability and activities of daily living of brain glioma patients ,the mechanisms of which could be the increase of cortex blood perfusion and theincrease of neuropeptide levels .