经尿道超脉冲等离子电切术联合内分泌治疗中晚期前列腺癌60例疗效观察

Observation of the clinical effects of TUPKP /SP combined with endocrine-therapy in the treatment of middle and advanced prostate cancer

目的探讨经尿道超脉冲等离子电切术(TUPKP/SP)联合内分泌疗法治疗中晚期前列腺癌的临床疗效。方法对60例中晚期前列腺癌患者采用经尿道超脉冲等离子电切术(TUPKP/SP)联合内分泌疗法治疗,对治疗的效果进行观察。结果 60例患者的平均手术时间为(55.3±11.2)min,术中平均出血量为(64.8±17.5)ml,术后平均留置导尿管时间为(5.5±2.4)d,未发生电切综合征及其他严重并发症。所有患者均随访6个月以上,未发现有血行转移;手术前后患者的国际前列腺评分(IPSS)、生活质量评分(QOL)、剩余尿量(RU)明显降低,最大尿流率(Qmax)明显升高,差异均具统计学意义(P<0.05)。结论经尿道超脉冲等离子电切术联合内分泌疗法可作为中晚期前列腺癌患者的姑息性治疗措施,可迅速、安全有效地解除下尿路梗阻,提高患者的生活质量,值得临床推广应用。

Objective To observe the clinical effects of TUPKP/SP combined with endocrine therapy in the treatment of middle and advanced prostate cancer. Methods 60 patients with middle and advanced prostate cancer were selected and treated with TUPKP/SP combined with endocrine therapy. The effect of the treatment was observed. Results The average operation time was 55.3 ± 11.2min, the average amount of bleeding during operation was 64.8 ±17.5ml and the mean indwelling catheter time was 5.5 ± 2.4d. There were no transurethral resection syndrome and other complications. All the patients were followed up for over 6 months and no hematogenous metastasis occurred. Compared with the preoperative condition, the scores of IPSS, QOL and the RU significantly decreased, while the Qmax increased significantly （P 〈 0. 05）. Conclusions TUPKP/SP can be used as a palliative treatment of middle and advanced prostate cancer. It can rapidly, effectively relieve lower urinary trnat nhgtnlotJnn and improve the quality life of patients. It is worth generalizing.