幽门螺杆菌基因多态性及其致病机制研究进展

Research progress on genetic polymorphism and pathogenesis of Helicobacter Pylori

幽门螺杆菌是一种全球范围内的慢性感染性致病菌,除导致慢性胃炎、消化性溃疡、胃癌等胃肠疾病外,还与慢性心血管疾病,肝脏及胆道疾病密切相关。研究表明,其基因结构多态性差异是导致不同临床表现的主要原因,近年来对Hp毒力因子及其基因多态性研究取得长足进展,本文对其主要的毒力基因多态性及可能的致病机制进行综述。

Helicobacter pylori( Hp) is a worldwide chronic infectious pathogens,except for gastrointestinal disease such as chronic gastritis,peptic ulcer and gastric cancer,Hp infection is also closely related to the chronic cardiovascular disease,liver and biliary tract diseases. It is report that the difference in gene polymorphism is the main reason for the different clinical manifestations. In this review article,we focus on the gene polymorphism and pathogenic mechanism of Hp.