安理申联合金纳多治疗血管性痴呆50例临床分析

The Clinical Curative Effect Analysis of 50 Patients with Vascular Dementia in Treated by Donepezil combined with Ginaton

目的:观察安理申联合金纳多对血管性痴呆患者的临床疗效和安全性。方法:将2010年1月至2013年6月收治的血管性痴呆患者100例随机分成对照组和观察组各50例,对照组单用安理申治疗,观察组联合安理申和金纳多治疗,16周为一个疗程,比较两组治疗前、后简易智能精神状态检查表(MMSE)和日常生活活动能力表(ADL)积分,以评价临床疗效。结果:两组治疗后的MMSE评分均较治疗前明显改善,但观察组的认知功能和行为能力的改善均明显优于对照组(P<0.05),而不良反应无明显增加。结论:安理申联合金纳多改善血管性痴呆患者认知功能和日常生活能力的临床疗效确切且安全。

Objective：To observe the clinical curative effect and safety of Donepezil combined with Ginaton in treating vascular dementia. Methods： 100 patients with vascular dementia from Jan 2010 to Jun 2013 were randomly divided into control group and observation group, and each group was 50 cases. The control group was treated with Donepezil only, while the observation group treated with Donepezil combined with Ginaton, 16 weeks as a treatment course. The clinical efficacies were compared before and after treatment evaluated by the Mini Mental State Examination （MMSE） and the activity of daily living（ADL） scores between the two groups. Results： MMSE scores were significantly better after treatment than before treatment in both groups, hut the observation group had more evident changes of the MMSE and ADL scores comparison showing statistical signifieance（P 〈 0.05） without obvious increase of adverse reactions. Conclusion：Donepezil combined with Ginaton in treating vascular dementia can significantly improve the MMSEd and ADL scores with definite clinical efficacy and safety.