IL-8和ET-1在慢性阻塞性肺疾病急性加重合并肺栓塞的表达及临床意义

Expression and clinical significance of IL-8 and ET-1 in AECOPD and PE patients

目的探讨慢性阻塞性肺疾病急性加重(AECOPD)合并肺栓塞(PE)患者血清中白细胞介素-8(IL-8)和内皮素-1(ET-1)含量的变化及临床意义。方法收集AECOPD患者62例,其中单纯AECOPD患者38例,AECOPD+PE患者24例,另取同期健康体检者40例作为对照组,采用酶联免疫吸附试验测定3组血清中的IL-8和ET-1含量。结果①AECOPD组和AECOPD+PE组患者血清IL-8和ET-1水平明显高于对照组(P<0.05);②AECOPD+PE组血清IL-8和ET-1水平明显高于AECOPD组(P<0.05);③AECOPD组和AECOPD+PE组患者血清中IL-8和ET-1与呈正相关;④AECOPD组和AECOPD+PE组Fbg、t-PA含量均较对照组有显著升高,PT、APTT指标较对照组均显著缩短,TT显著延长(P<0.05)。结论 IL-8和ET-1的异常表达在AECOPD合并肺栓塞的发生发展中起一定的作用,联合检测IL-8和ET-1有助于AECOPD患者病情严重程度的判断。

【Objective】Objective To investigate the changes and clinical significance of IL-8 and ET-1 in patients with AECOPD and PE.【Methods】Sixty-two patients with AECOPD were collected, 38 patients with AECOPD and 24patients with COPD complicated PE,40 healthy people were assigned to the control group, Enzyme-linked immunosorbent assay was used to detect the expression of IL-8 and ET-1.【Resluts】① The serum level of IL-8 and ET-1 in AECOPD and AECOPD＋PE groups were significantly higher than those in control group; ② The serum level of IL-8 and ET-1in AECOPD＋PE group was significantly higher than those in AECOPD; ③ The serum level of IL-8 in AECOPD and AECOPD＋PE groups was positively correlated with ET-1; ④ The level of Fbg and t-PA in AECOPD and AECOPD＋PE groups were significantly higher than those in control group, the PT and APTT was shortened obviously than those in control group（P0.05）.【Conclusion】Abnormal expression of IL-8 and ET-1 may have effection on the development of AECOPD＋PE, combined detection of IL-8 and ET-1 may provide a basis for AECOPD severity diagnosis.